Open Herald: Periodical of Methodical Research

Molecular Docking, Synthesis and Antibacterial activity of sulphdiazine drug modification and studying their PC3 by MTT

Sadiq S. Sadiq

Department of Medical Lab Technique, College of Health and Medical Technology Sawa University, Al-Muthana, Iraq

Raghad Haddad

Alkarkh university of science, Baghdad, Iraq. raghadalihaddad@gmail.com 3 Chemistry Department, College of Science, AL-Nahrain University, Jadriya, Baghdad, Iraq.

Hassan Hadi Kadhim

Chemistry Department, College of Science, AL-Nahrain University, Jadriya, Baghdad, Iraq

Abbas K. Abbas

Muthana Agriculture Directorate, Ministry of Agriculture, Al-Muthana, Iraq

Ruqaya K. Abbas

Ibnsina university for pharmacy and medical science, Baghdad, Iraq

Keywords: Imine, Sulfadiazine, Schiff base

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Abstract

In this study, we report a novel imine-amoxicillin synthesis (A1-A3) by reacts Sulfadiazine with different aldehydes such as 2-bromobenzaldehyde, 4-propoxybenzaldehyde, and 4- butoxybenzaldehyde. The derivatives (A1-A3) were characterized by spectroscopic technique, such as FT‐IR and 1H-NMR spectroscopy. All the synthesized derivatives were evaluated in vitro against different microorganisms such as Bacillus subtilis, Streptococcus pneumonia, E. coli, and Bacillus subtilis by zone inhibition method. The findings demonstrated that certain derivatives exhibit superior antibacterial properties in comparison to the efficacy of the original drug. The evaluation of derivative 1 as anticancer (breast cancer) by MTT assay and give a positive result after 24 h more than 48 h.

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