Evaluation of the effectiveness of α1-blockers in the treatment of patients with ureteral stones
Kasimov S.S
Tashkent Medical Academy, Uzbekistan, Tashkent.
Abdukarimov O.O
Tashkent Medical Academy, Uzbekistan, Tashkent.
Keywords: blockers, ureteral stones, drug treatment
Abstract
The results of a study assessing the effectiveness of the use of α1-blockers in the complex treatment of ureteral calculi are presented. A comparative prospective single-center study was conducted, which included 118 patients with single diagnosed stones in various parts of the ureter. After pain relief, all patients underwent conservative therapy aimed at spontaneous passage of stones. The maximum duration of conservative treatment was 30 days. All patients underwent weekly ultrasound monitoring.
References
Kaid-Omar Z., Belouatek A., Driouch A. et al. Effects of diuretic therapy on spontaneous expulsion of urinary calculi, urinary pH, and crystalluria in lithiasic patients. Prog. Urol. 2001;11:450–454.
Worster A., Richards C. Fluids and diuretics for acute ureteric colic. Cochrane Database. Sys. Rev. 2005; СD 004926.
Weiss R. M. Physiology and Pharmacology of the renal pelvis and ureter. In Cambell’s Urology (P. C. Walsh, A. B. Retik, T. A. Stamey, E. D., E. D. Vaughan eds). 7 th edn, Vol. 1, Chapt. 25. Philadelphia: WB Saunders Co., 1999;839–869.
Lang R. J., Hashitani H., Tonta M. A. et al. Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis. J. Physiol. 2007;583:1049–1068.
Lang R. J., Tonta M. A., Beata Z. Zolotkowski et al. Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers. J. Physiol. 2006;576:695–705.
Lang R. J., Tonta M. A., Beata Z. Zolotkowski et al. Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers. J. Physiol. 2006;576:695–705.
Rose J. G., Gillenwater J. Y. The effect of adrenergic and cholinergic agents and their blockers upon ureteral activity. Invest. Urol.n1974;11:439–441.
Ross J. A., Edmond P., Griffiths J. M. The action of drugs on the intact human ureter. Br. J. Urol. 1967;39:26–29.
Sigala S., Dellabella M., Milanese G. Evidence for the presence of alpha1-adrenoceptor subtypes in the human ureter. Neurourol. Urodyn. 2005;24:142–148.
Hyoung K. P., Eun Y. C., Byong C. J. et al. Localizations and expressions of α1A, α1-1B and α1-1D adrenoceptors in human ureter. Urol. Res. 2007;35:325–329.
O’Leary M. P. Tamsulosin (current clinical experience). Urology. 2001;58(Suppl. 6):42–48.
Hartrick C. T., Kovan J. P., Shapiro S. The numeric rating scale for clinical pain measurement: a ratio measure? Pain. Pract. 2003;3(4):310–316.
Griffiths D. J. The mechanics of urine transport in the upper urinary tract. 2. The discharge of the bolus into the bladder and dynamics at high rates of flow. Neurourol. Urodyn. 1983;2:167–177.
Crowley A. R., Byrne J. C., Vaughan Jr. E. D. et al. The effect of acute obstruction on ureteral function. J. Urol. 1990;143:596–599.
Gasser H. S., Grundfest H. Axon diameters in relation to the spike dimensions and the conduction velocity in mammalian A-fibers. Amer. J. Physiol. 1939;127:393–397.
Dixon J. S., Gosling J. A. The musculature of the human renal calices, pelvis and upper ureter. J. Anatomy. 1973;135:129–137.
McLeod D. G., Reynolds D. G., Swan R. G. Adrenergic mechanisms in the canine ureter. Am. J. Physiol. 1973;224:1054–1059.
Davenport K., Timoney A. G., Keeley F. X. A comparative in vitro study to determine the beneficial effect of calcium-channel and a1-adrenoceptor antagonism on human ureteric activity. B.J.U. Int. 2006;98(3):651–655.
Davenport K., Timoney A. G., Keeley Jr F. X. Effect of smooth muscle relaxant drugs on proximal human ureteric activity in vivo: a pilot study. Urol. Res. 2007;35:207–213.