Published
2025-01-25
Section
Articles
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Copyright (c) 2025 Karrar Mohammed Gaila, Atyaf Qusay Kadhim, Mokhalad Waheeb Abdullah, Abbas K. Abbas, Hind S. Sedeeq, Zahraa M. abdnoor
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Microwave Assisted Synthesis, Spectroscopy Characterization of Amoxicillin Linked Azomethine as Medical Applications
Karrar Mohammed Gaila
Health Management Department, Sawa University, Al-Muthanna, Iraq.
Atyaf Qusay Kadhim
Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Mokhalad Waheeb Abdullah
Ministry of Education / Diyala Education Directorate, Diyala, Iraq.
Abbas K. Abbas
Muthana Agriculture Directorate, Ministry of Agriculture, Al-Muthana, Iraq.
Hind S. Sedeeq
Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.
Zahraa M. abdnoor
Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Keywords: Azomethine, Amoxicillin
Abstract
In this study, a new amoxicillin linked azomethine synthesis (A1-A3) by reacting amoxicillin with different aldehydes such as 2-hydroxy5-hexylBenzaldehyde, 4- Hexoxybenzaldehyde, and 2-methoxybenzaldehyde. FT-IR characterized the derivatives (A1-A3). All the derivatives (A1-A3) were evaluated against microorganisms such as Streptococcus pneumonia and E. coli by zone inhibition method. The findings demonstrated that certain derivatives exhibit superior antibacterial properties in comparison to the efficacy of the original drug. The produced azomethine derivative A1 has the most promising antimicrobial properties against Staphylococcus aureus by zone inhibition 23 mm at higher dosages. However, derivative A2 reduced efficacy at lower dosages requires more investigation to improve potency and stability. Evaluation of prostate cancer (PC3) by using MTT assay that gives a positive result at high concentration.
